Submitted: 01 Jan 2017
Accepted: 05 Oct 2017
First published online: 12 Nov 2017
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Avicenna J Med Biochem. 2017;5(2):65-69.
doi: 10.15171/ajmb.2017.12
  Abstract View: 68
  PDF Download: 52

Research Article

The Assessment of 25-Hydroxy Vitamin D Serum Level in Asthmatic Patients: A Case-Control Study

Mohammad Rasoul Sharanjani 1, Ebrahim Nadi 2, Maryam Vasheghani 3 * ORCiD, Mohammad Jafari 4, Jalal Poorolajal 5

1 Department of Internal Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Pulmonology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3 Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Pathology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
5 Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
Corresponding Author: Maryam Vasheghani, Chronic Respiratory Diseases Research Center, Masih Daneshvari Hospital, Pourebtehaj Street, Niavaran, Tajrish Square, Tehran, Iran. Post Box: 19575- 154, Post Code: 19569-44413 Tel: +982127122012; Fax: +982126109930 Email:


Background: The prevalence of vitamin D deficiency is increasing due to changes in lifestyle and dietary habits. The aim of this study was to compare the serum levels of 25-hydroxy vitamin D between patients with bronchial asthma and the healthy control group.

Patients and Methods: In this case-control study, 45 patients with asthma and 45 healthy subjects were enrolled and the level of serum 25 (OH) vitamin D was measured in both groups. In addition, a welltrained observer assessed airway reversibility, peak flowmetry and spirometry in the participants. The data were statistically analyzed using t test, one-way analysis of variance (ANOVA), and chi-square test with Stata software (version 11).

Results: The mean age (±SD) of participants were 49.06 ±16.43 and 46.13 ±16.10 years in case and control groups, respectively (P=.394). The prevalence of vitamin D deficiency was high in both groups (69% in case and 65.5% in control groups). The mean (±SD) serum 25 (OH) vitamin D was 16.24 (±14.98) ng/ml in case group and 17.70 (±16.07) ng/mL in control group (P=.657). We found a positive correlation between the levels of vitamin D and the amount of FEV1 (r=0.2).

Conclusions: According to the present study, the mean serum levels of vitamin D differences were not statistically significant between asthmatic patients and control group. However, the results of this study showed a positive relationship between forced expiratory volumes in first second (FEV1) and vitamin D levels

© 2017 The Author(s); Published by Hamadan University of Medical Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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