Submitted: 01 Jan 2017
Accepted: 05 Oct 2017
First published online: 12 Nov 2017
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Avicenna J Med Biochem. 2017;5(2):65-69.
doi: 10.15171/ajmb.2017.12
  Abstract View: 68
  PDF Download: 52

Research Article

The Assessment of 25-Hydroxy Vitamin D Serum Level in Asthmatic Patients: A Case-Control Study

Mohammad Rasoul Sharanjani 1, Ebrahim Nadi 2, Maryam Vasheghani 3 * ORCiD, Mohammad Jafari 4, Jalal Poorolajal 5

1 Department of Internal Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Pulmonology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3 Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Pathology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
5 Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
Corresponding Author: Maryam Vasheghani, Chronic Respiratory Diseases Research Center, Masih Daneshvari Hospital, Pourebtehaj Street, Niavaran, Tajrish Square, Tehran, Iran. Post Box: 19575- 154, Post Code: 19569-44413 Tel: +982127122012; Fax: +982126109930 Email: mvasheghani9@gmail.com

Abstract

Background: The prevalence of vitamin D deficiency is increasing due to changes in lifestyle and dietary habits. The aim of this study was to compare the serum levels of 25-hydroxy vitamin D between patients with bronchial asthma and the healthy control group.

Patients and Methods: In this case-control study, 45 patients with asthma and 45 healthy subjects were enrolled and the level of serum 25 (OH) vitamin D was measured in both groups. In addition, a welltrained observer assessed airway reversibility, peak flowmetry and spirometry in the participants. The data were statistically analyzed using t test, one-way analysis of variance (ANOVA), and chi-square test with Stata software (version 11).

Results: The mean age (±SD) of participants were 49.06 ±16.43 and 46.13 ±16.10 years in case and control groups, respectively (P=.394). The prevalence of vitamin D deficiency was high in both groups (69% in case and 65.5% in control groups). The mean (±SD) serum 25 (OH) vitamin D was 16.24 (±14.98) ng/ml in case group and 17.70 (±16.07) ng/mL in control group (P=.657). We found a positive correlation between the levels of vitamin D and the amount of FEV1 (r=0.2).

Conclusions: According to the present study, the mean serum levels of vitamin D differences were not statistically significant between asthmatic patients and control group. However, the results of this study showed a positive relationship between forced expiratory volumes in first second (FEV1) and vitamin D levels

© 2017 The Author(s); Published by Hamadan University of Medical Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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