Submitted: 05 Jan 2017
Accepted: 20 May 2017
First published online: 03 Jun 2017
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Avicenna J Med Biochem. 2017;5(2):87-91.
doi: 10.15171/ajmb.2017.16
  Abstract View: 69
  PDF Download: 53

Research Article

Is There Relation Between 25(OH) Vitamin D and Chronic Obstructive Pulmonary Disease?

Farshid Divani 1, Alireza zahedi 1 * ORCiD, Maryam Vasheghani 2, Ebrahim Nadi 1, Jalal Poorolajal 3, Mohammad Jafari 4, Mohammad Faryadres 5

1 Department of Internal Medicine, Hamadan university of Medical Sciences, Hamadan, Iran
2 Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis And Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Modeling of Noncommunicable Diseases Research Center, Department of Epidemiology & Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
4 Department of Pathology, Ekbatan Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
5 Department of Epidemiology & Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
Corresponding Author: Alireza Zahedi, Department of Internal Medicine, Hamedan university of Medical Sciences, P.O. Box 65179-5-337, Hamadan, Iran.Tel: +989183198092 Email:


Background: Vitamin D level can affect pulmonary function in patient who have chronic obstructive pulmonary disease (COPD).

Objectives: There are few studies that assess this subject, so we investigate the relation of Vitamin D and COPD.

Materials and Methods: A case-control study was conducted among the patients referred to the pulmonology clinic of Shahid Beheshti hospital of Hamadan, in which 68 of patients were assigned into the case group with COPD and 68 patients into the control group. Both groups were evaluated for respiratory differences as clinical or laboratory and the blood level of vitamin D was measured.

Results: Of 136 evaluated participants with the mean age of 58.83 years old, 68 patients were studied as case group consisting of 2 females and 66 males. The results suggested that the serum level of vitamin D in COPD patients and control group patients were 22.22 ± 15.83 ng/mL and 27.47 ± 21.43 ng/mL, respectively. It was also found that there was a positive correlation between lung function and serum level of vitamin D in COPD. The greater the severity of COPD (forced expiratory volume in the first second [FEV1] lower level) was, the more the vitamin D deficiency was seen. It was also clarified that there was an indirect correlation between the serum level of vitamin D in COPD patients and body mass index (BMI).

Conclusions: Prevalence of vitamin D deficiency in COPD patients was more than that in control group patients. Due to the growing prevalence of vitamin D deficiency in such patients, any use of vitamin D maybe suggested.

© 2017 The Author(s); Published by Hamadan University of Medical Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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