Submitted: 11 Jun 2017
Accepted: 01 Dec 2017
First published online: 23 Dec 2017
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Avicenna J Med Biochem. 2017;5(2):70-75.
doi: 10.15171/ajmb.2017.13
  Abstract View: 12
  PDF Download: 11

Research Article

Improved glucose and IL-6 by aerobic training despite no change in insulin and insulin resistance in obese women

Mojtaba Eizadi 1 * ORCiD, Maryam Farbod 2, Mohammad Taghi Goodarzi 3, Zohreh Afsharmand 3

1 Assistant Professor of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, Iran
2 Professor of Clinical Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran
3 Assistant Professor of Physical Education and Sport Sciences, Amirkabir University of Technology, Tehran, Iran
Corresponding author: Mojtaba Eizadi, Tel: 09193551960 Email: izadimojtaba2006@yahoo.com

Abstract

Background: Regular physical activity is recognized as a non-pharmacological treatment of inflammation and glycemic profile.

Objectives: This exercise aimed to determine the effect of aerobic training on serum interleukin-6 (IL-6), glucose and insulin resistance in obese females.

Patients and Methods: Thirty-two middle-aged obese women (body mass index [BMI], 32 ± 3 kg/m2) aged 35 to 45 years were randomly assigned to exercise (aerobic training, n=16) and control (n=16) groups. Exercise subjects were completed a 12 weeks aerobic training program as 3 sessions per week at 60%-80% of HRmax and control subjects received no training. Pre- and post-training of fasting serum IL-6, insulin, insulin resistance, and glucose concentration were measured and compared between 2 groups. Results were compared using t test at a significance level of P<0.05.

Results: Exercise group obtained significant decreases in BMI, body fat %, and abdominal obesity as well as the concentrations of serum IL-6 and fasting glucose (P<0.05). No significant difference was observed between pre- and post-training of insulin and insulin resistance in the exercise group (P >0.05). There were no alterations in these variables in the control group (P>0.05).

Conclusions: These data suggest that aerobic training may improve glycemic profile in absence of change in insulin resistance of women with abdominal obesity

© 2017 The Author(s); Published by Hamadan University of Medical Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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