Logo-ajmb
Submitted: 28 Apr 2013
Revision: 24 Jul 2013
Accepted: 16 Aug 2013
ePublished: 28 Sep 2013
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Avicenna J Med Biochem. 2013;1(1): 7-13.
  Abstract View: 1488
  PDF Download: 1432
  Full Text View: 1099

Research Article

Anti-diabetic effects of aqueous extracts of three Iranian medicinal plants in type 2 diabetic rats induced by high fructose diet

Mohammad Taghi Goodarzi 1*, Amir Sasan Tootoonchi 1, Jamshid Karimi 2, Ebrahim Abbasi Oshaghi 3

1 Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2 Deptartment of Biochemistry and Nutrition, Hamadan University of Medical Sciences, Hamadan, Iran
3 Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding Author: Mohammad Taghi Goodarzi Tel:+98 8118380462 Fax:+988118390208 , Email: mt.goodarzi@umsha.ac.ir

Abstract

Objectives: Insulin resistance has been considered as the most important component of type 2 diabetes mellitus (DM2). Plants used in folk medicine to treat diabetes mellitus represent a viable alternative for the control of this disease. This study was aimed to examine the antidiabetic effects of three Iranian medicinal plants i.e. Urtica dioica, Trigonella foenum-graecum and Fumaria officinalis in an animal model of DM2.

Methods: Diabetes was induced in male Wistar rats (6-8 weeks old) by feeding 21% fructose in drinking water for 8 weeks. They were treated with aqueous extracts (10%) of three medicinal plants (Urtica dioica, Trigonella foenum-graecum and Fumaria officinalis) for 8 weeks. After diabetes induction and the last day of the  experiment, body weight, fasting blood glucose, plasma insulin, urine volume and glucose were assayed.

Results: Blood glucose, plasma insulin, urine glucose and urine volume were increased significantly after 8 weeks of high fructose feeding (P<0.05); the aqueous extracts of Urtica dioica reduced the blood and urine glucose and also the aqueous extracts of Trigonell Foenum diminished the insulin, weight and blood glucose in
comparison with the high fructose-fed control group (P<0.05).

Conclusion: The obtained data in this study showed hypoglycemia effects of Trigonell Foenum and Urtica dioica extracts. Also our findings indicated that the hypoglycemia effect of Trigonell Foenum extract is in part by improvement of insulin resistance. These results can be extrapolated to humans and these extracts might be
useful in the treatment of insulin resistance.


Citation:
Goodarzi MT, Tootoonchi AS, Karimi J, Abbasi Oshaghi E. Anti-diabetic effects of aqueous ex-tracts of three Iranian medicinal plants in type 2 diabetic rats in-duced by high fructose die. Avi J Med Biochem. 2013; 1(1): 7-13.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 1489

Your browser does not support the canvas element.


PDF Download: 1432

Your browser does not support the canvas element.


Full Text View: 1099

Your browser does not support the canvas element.