Abstract
Background: Based on clinical studies, low adiponectin and high tumor necrosis factor alpha (TNF-α) are
associated with obesity and related diseases such as type 2 diabetes and insulin resistance.
Objectives: In this study, we aimed to investigate the effect of an aerobic training program on adiponectin,
TNF-α, and adiponectin/TNF-α ratio in adult obese men.
Patients and Methods: For this purpose, 24 sedentary adult obese men matched for age (38 ± 3.23 years)
and body mass index (31.94 ± 3.26 kg/m2
) were selected and divided into exercise (aerobic training)
and control groups. Exercise subjects participated in an aerobic exercise training intervention for 12
weeks (3 times/week) and the control group did not participate in aerobic intervention. Anthropometric
and biochemical data including fasting serum adiponectin, TNF-α, and adiponectin/TNF-α ratio were
measured before and after aerobic training for each participant in each group. Data were analyzed by
both independent and paired sample t test.
Results: Compared to pre-training, fasting serum adiponectin decreased significantly (P = .019), but
serum TNF-α was not changed by aerobic training (P = .057). A significant increase was observed in
adiponectin/TNF-α ratio in exercise subjects after aerobic training (P = .008).
Conclusions: Based on these data, we conclude that aerobic training intervention is associated with
improved inflammatory profile in obese subjects.