Submitted: 11 Mar 2018
Accepted: 04 Jun 2018
First published online: 26 Jun 2018
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)

Avicenna J Med Biochem. 2018;6(1):15-20.
doi: 10.15171/ajmb.2018.04
  Abstract View: 110
  PDF Download: 121

Research Article

Impact of Whole Plant Extract of Pergularia daemia on Glycoproteins in Dimethylbenz(A)Anthracene Induced Hamster Buccal Pouch Carcinogenesis

Vaithiyanathan Veluchamy 1 ORCID logo, Mirunalini Sankaran 1 * ORCID logo

1 Department of Biochemistry & Biotechnology, Annnamalai University, Annamalainagar, Chidambaram, India
*Corresponding author: Department of Biochemistry & Biotechnology, Annnamalai University, Annamalainagar, Chidambaram, Tamilnadu- 608 002. India. Tel: 09442424438, Country code: +91, Fax: 04144 238 080, Email: mirunasankar@gmail.com


Background: Oral squamous cell carcinoma is a major component of a diverse group of neoplasms often referred to as ‘head and neck cancer’. Frequent smoking and/or alcohol consumption are two major risk factors for oral cancer. Objectives: The present study was aimed to investigate the protective role of Pergularia daemia ethyl acetate and methanolic extracts (PDEAE and PDME, respectively) on glycoproteins in dimethylbenz(a) anthracene (DMBA) induced hamster buccal pouch carcinogenesis.

Materials and Methods: Male golden Syrian hamsters were used and divided into six groups. Group 2 carried 0.5% 7,12-DMBA painting on left buccal pouch. Groups 3 and 4 were treated with DMBA and 300 mg/kg bwt of PDEAE and PDME by intragastric administration. Remaining groups served as untreated control. All the experiments were performed within 14 weeks.

Results: Body weight loss and 100% tumor incidence were observed treated hamsters with DMBA alone, whereas administration of PDEAE and PDME in animals with oral cancer caused significant alterations in body weight and tumor incidence. Further, plasma and buccal pouch tissue glycoprotein levels were increased and erythrocyte glycoprotein levels were depleted in DMBA treated hamsters. The levels were significantly reversed in hamsters treated with PDEAE and PDME at 300 mg/kg bwt.

Conclusion: PDEAE and PDME produce a significant protective effect against DMBA induced oral cancer by altering glycoproteins levels.

Keywords: Pergularia daemia, Hamsters, Dimethylbenz(a)anthracene, Glyco proteins, Histopathology,
First name
Last name
Email address
Security code

Article Viewed: 110

Your browser does not support the canvas element.

PDF Downloaded: 121

Your browser does not support the canvas element.