Submitted: 15 Sep 2017
Accepted: 25 Nov 2017
First published online: 10 Dec 2017
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Avicenna J Med Biochem. 2017;5(2):60-64.
doi: 10.15171/ajmb.2017.11
  Abstract View: 161
  PDF Download: 130

Research Article

Total antioxidant capacity, lipid peroxidation, thiol group and catalase activity in patients with kidney stone

Farshad Rostampour 1, Hadi Ghasemi 1, Seyyd Habibollah Mousavi-bahar 2, Akram Ranjbar 3, Tavakol Heidary Shayesteh 2, Heidar Tayebinia 3 * ORCiD

1 Students Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2 Urology and Nephrology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
Corresponding author: Heidar Tavilani, Email: tavilani@gmail.com, tayebinia@umsha.ac.ir Email: tayebinia@umsha.ac.ir

Article

Background: Urinary tract stones are one of the most common causes of kidney disease. There is evidence for the possible involvement of oxidative stress in the formation of kidney stones and renal cell injury.

Objectives: In this study, we aimed to determine the total antioxidant capacity (TAC), malondialdehyde (MDA), serum thiol group, ceruloplasmin (CP) levels and catalase (CAT) activity in the serum of the patients with kidney stones.

Materials and Methods: This study was conducted as a case-control study. A total of 31 patients (16 males and 15 females) with kidney stone(s) and a comparative normal control group including 21 (12 males and 9 females) healthy subjects were included.

Results: The present study revealed that TAC level was significantly higher in the control group (P=0.004), and the mean thiol group was remarkably decreased in the patient group (P<0.001). Moreover, CAT activity decreased in the patients but it was not significant (P=0.23). On the other hand, the findings showed that the serum CP level significantly increased in the patient group (P<0.001). MDA level also increased in the patient group, although this increment was not significant (P=0.87).

Conclusions: It can be concluded that the reduction of antioxidant indices in the patients with kidney stones can damage the renal tubular cells and strengthen the accumulation of crystals and the formation of kidney stones.

© 2017 The Author(s); Published by Hamadan University of Medical Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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