Submitted: 11 Sep 2019
Accepted: 23 Oct 2018
ePublished: 10 Dec 2018
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Avicenna J Med Biochem. 2018;6(2): 31-36.
doi: 10.15171/ajmb.2018.08
  Abstract View: 148
  PDF Download: 169

Research Article

The Effects of Subcutaneous Administration of Granulocyte Colony-Stimulating Factor on Pregnancy Outcome After Assisted Reproductive Technology: Clinical Trial

Marzie Farimani 1 ORCID logo, Narges Mehrabi 2, Azar Pirdehghan 3, Maryam Bahmanzadeh 1,4 * ORCID logo

1 Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Obstetrics & Gynecology, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Community and Preventive Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4 Department of Anatomical Sciences, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


Background: Granulocyte-colony stimulating factor (G-CSF) is an innovative therapy in reproductive medicine. Although its mechanisms of action have remained unknown, G-CSF seems to be effective in the case of recurrent abortion or implantation failure and thin endometrium.

Objectives: This study was conducted to investigate whether subcutaneous administration of G-CSF has any effect on pregnancy outcome after assisted reproductive technology (ART). Methods: Fifty women with male infertility factors undergoing ART treatment were enrolled and stimulated with the standard long protocol. The G-CSF group of women received one dose of subcutaneous G-CSF (Filgrastim, 300 µg/1 mL) on the day of embryo transfer and again two days later while the placebo group received normal saline.

Results: Seventeen patients had a positive β-human chorionic gonadotropin concentration after embryo transfer (8 and 9 in G-CSF and placebo groups, respectively) although the difference was not statistically significant. In addition, spontaneous abortion occurred in three patients (1 patient in the G-CSF group vs. 2 patients in the placebo group).

Conclusion: Overall, although G-CSF failed to affect the endometrial thickness, as well as implantation, or clinical pregnancy rates, a lower prevalence of abortion in G-CSF group may be due to the positive effect of G-CSF administration on the endometrium as compared to the placebo group.

Keywords: Assisted Reproductive Technology, Granulocyte-colony Stimulating Factor, Miscarriage, Implantation,
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