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Submitted: 07 Jul 2019
Accepted: 10 Nov 2018
First published online: 26 Dec 2018
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Avicenna J Med Biochem. 2018;6(2):37-43.
doi: 10.15171/ajmb.2018.09
  Abstract View: 26
  PDF Download: 38

Research Article

Protective Role of Ce Nanoparticles Against the Hepatotoxicity Induced by Exposure to Paraquat

Hamid Heidary Dartoti 1 ORCID logo, Farzin Firozian 2, Sara Soleimani Asl 3, Akram Ranjbar 4 * ORCID logo

1 Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Pharmaceutical, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
3 Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4 Nutrition Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

Abstract

Objectives: The present study aimed to investigate the antioxidant activity of cerium oxide nanoparticles (CeNPs) against paraquat (PQ)-induced liver injury in rats.

Methods: Thirty-two male rats were divided into four 8-member groups and treated intraperitoneally with PQ and/or CeNPs for 14 days. Group 1 received PQ (5 mg/kg/d), group 2 received CeNPs (15, 30, and 60 mg/kg/d), group 3 received a combination of PQ (5 mg/kg/d) and CeNPs (15, 30, and 60 mg/kg/d), and group 4 (control group) received saline solution. Serum samples along with liver tissue samples were collected from all the rats. Oxidative stress (OS) biomarkers including total antioxidant capacity, lipid peroxidation, total thiol groups, DNA damage, and nitric oxide levels were determined. Histological samples were also analyzed using hematoxylin and eosin staining slides.

Results: Levels of oxidative stress and hepatic tissue damage were significantly higher in the PQ group compared to the control group. CeNPs at a dose of 15 mg/kg showed the antioxidant activity and compromised the PQ-induced damage.

Conclusion: In the scenario tested in this study, CeNPs could reduce the levels of OS, as well as hepatic damage induced by PQ.

Keywords: Cerium oxide nanoparticle, Paraquat, Oxidative stress, Liver,
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