Submitted: 28 Sep 2020
Accepted: 09 Nov 2020
ePublished: 30 Dec 2020
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Avicenna J Med Biochem. 2020;8(2): 53-57.
doi: 10.34172/ajmb.2020.08
  Abstract View: 362
  PDF Download: 200

Research Article

Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress

Somayyeh Mohammadi Pasand 1, Akram Ranjbar 1, Nejat Kheiripour 2, Hassan Ghasemi 3, Hassan Rafieemehr 4* ORCID logo

1 Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
3 Department of Clinical Biochemistry, Abadan School of Medical Sciences, Abadan, Iran
4 Department of Medical Laboratory Sciences, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding author: Hassan Rafieemehr, Department of Medical Laboratory Sciences, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran. Tel: +98 8138381037, Fax: +98 8138381017, Email: rafee135298@gmail. com


Objectives: Aluminum phosphide (AIP) is the commonly used pesticide in agriculture, which induces oxidative stress in almost all major body systems and organs. The aim of this study was to evaluate the efficacy of nanocurcumin and curcumin on serum oxidative stress level in subacute toxicity with AIP.

Materials and Methods: In this study 36 male Wistar rats (220-250 g) were randomly divided into six groups. Control (C) receiving normal saline; group AIPreceiving AIP (2 mg/kg daily); group Cur receiving curcumin (100 mg/kg daily); group Nano-cur receiving nanocurcumin (100 mg/kg daily); group AIP+ Cur receiving AIP (2 mg/kg daily) and curcumin (100 mg/kg daily); and group AIP and Nano-cur receiving AIP (2 mg/kg daily) and nanocurcumin (100 mg/kg daily). Serum total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol groups (TTG), and catalase (CAT) activity were measured.

Results: AIP administration led to a significant increase in LPO, and decreased the CAT activity, TAC, and TTG compared to the control group (P<0.05). Curcumin and nanocurcumin caused a significant decrease in the levels of LPO compared to the AIP-exposed groups (P<0.05). Moreover, in the nanocurcumin-treated groups, compared to a poisoned group, TAC and TTG increased significantly (P<0.01). There were no significant changes in CAT activity improvement.

Conclusion: Nanocurcumin and curcumin improved the AIP-induced oxidative damage.

Keywords: Nanocurcumin, Curcumin, Aluminum Phosphide, Serum,
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