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Submitted: 28 Oct 2020
Accepted: 30 Oct 2020
ePublished: 30 Dec 2020
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Avicenna J Med Biochem. 2020;8(2): 58-63.
doi: 10.34172/ajmb.2020.09
  Abstract View: 308
  PDF Download: 128

Research Article

Kiwifruit Supplementation Increases the Activity of the Paraoxonase Enzyme and decreases Oxidized Low-Density Lipoprotein in High-Fat Diet Fed Hamsters

Narjes Rezaei 1, Zahra Zaherijamil 1, Shirin Moradkhani 2, Massoud Saidijam 3, Iraj khodadadi 4, Ebrahim Abbasi Oshaghi 1, Heidar Tavilani 1* ORCID logo

1 Department of Clinical Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran.
2 Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
3 Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
4 Nutrition Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
*Corresponding author: Heidar Tavilani, Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Shahid Fahmideh Street, Hamadan, Iran. Email: tayebinia@umsha.ac.ir, tavilani@gmail.com

Abstract

Background: It is shown that kiwifruit elevates serum high-density lipoprotein cholesterol (HDL-C) levels and exhibits beneficial effects on human health due to its antioxidant potential.

Objectives: This study aimed to investigate the impact of kiwifruit on the activity of the paraoxonase 1 (PON1) enzyme, as a main antioxidant enzyme in HDL functionality, in a high-fat diet (HFD).

Methods: To this end, 42 male Syrian hamsters were divided into 6 groups including hamsters receiving a normal diet (the control normal group), a regular diet supplemented with kiwifruit at two concentrations (i.e., 1.86 g/kg and 3.73 g/kg), a HFD comprised of 15% butterfat + 0.05% cholesterol (the control high-fat group), and a HFD supplemented with kiwifruit at two concentrations (i.e., 1.86 and 3.73 g/kg) for 8 weeks.

Results: The results showed that supplementation of kiwifruit to the HFD increased the levels of HDL-C and remarkably reduced the concentrations of oxidized low-density lipoprotein (ox-LDL) and malondialdehyde (MDA) compared with the control-HF group. In addition, the paraoxonase activity of PON1 significantly increased in HFD supplemented with kiwifruit (1.86 g/kg), and finally, arylesterase (ARE) activity increased in all treated groups when compared with untreated groups.

Conclusion: Our findings suggested that kiwifruit can improve the lipid profile and prevent oxidative stress-induced by lipid peroxidation in hamsters receiving HFD, thus increasing the ARE and paraoxonase activities of PON1.

Keywords: Kiwifruit, Paraoxonase 1, Liver tissue, High-density lipoprotein, High-fat diet,
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