Abstract
The aim of this work was to study the antibacterial effects of cerium oxide nanoparticles prepared by alginate according the disc diffusion process. For this purpose, we used two Gram-positive [Bacillus subtilis (PTCC 1365) and Staphylococcus aureus ATCC 25923] and Gram-negative [Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 9027] bacterial strains. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values were measured by the microdilution method, and anti-biofilm activity of the synthetic material was also investigated. The results established the inhibitory properties of the synthetic nanoparticles on gram positive bacteria, where the growth percentage of S. aureus and B. subtilis was significantly hindered after exposure to the synthetic material.