Submitted: 11 Jun 2017
Accepted: 01 Dec 2017
First published online: 23 Dec 2017
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Avicenna J Med Biochem. 2017;5(2):70-75.
doi: 10.15171/ajmb.2017.13
  Abstract View: 319
  PDF Download: 259

Research Article

Improved glucose and IL-6 by aerobic training despite no change in insulin and insulin resistance in obese women

Mojtaba Eizadi 1 * ORCiD, Maryam Farbod 2, Mohammad Taghi Goodarzi 3, Zohreh Afsharmand 3

1 Assistant Professor of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, Iran
2 Professor of Clinical Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran
3 Assistant Professor of Physical Education and Sport Sciences, Amirkabir University of Technology, Tehran, Iran
Corresponding author: Mojtaba Eizadi, Tel: 09193551960 Email:


Background: Regular physical activity is recognized as a non-pharmacological treatment of inflammation and glycemic profile.

Objectives: This exercise aimed to determine the effect of aerobic training on serum interleukin-6 (IL-6), glucose and insulin resistance in obese females.

Patients and Methods: Thirty-two middle-aged obese women (body mass index [BMI], 32 ± 3 kg/m2) aged 35 to 45 years were randomly assigned to exercise (aerobic training, n=16) and control (n=16) groups. Exercise subjects were completed a 12 weeks aerobic training program as 3 sessions per week at 60%-80% of HRmax and control subjects received no training. Pre- and post-training of fasting serum IL-6, insulin, insulin resistance, and glucose concentration were measured and compared between 2 groups. Results were compared using t test at a significance level of P<0.05.

Results: Exercise group obtained significant decreases in BMI, body fat %, and abdominal obesity as well as the concentrations of serum IL-6 and fasting glucose (P<0.05). No significant difference was observed between pre- and post-training of insulin and insulin resistance in the exercise group (P >0.05). There were no alterations in these variables in the control group (P>0.05).

Conclusions: These data suggest that aerobic training may improve glycemic profile in absence of change in insulin resistance of women with abdominal obesity

© 2017 The Author(s); Published by Hamadan University of Medical Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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