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Submitted: 30 Apr 2014
Accepted: 02 Jun 2014
First published online: 25 Sep 2014
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Avicenna J Med Biochem. 2014;2(1): e18782.
doi: 10.17795/ajmb-18782
  Abstract View: 435
  PDF Download: 343
  Full Text View: 294

Research Article

Urtica dioica Effect on Malonyl-CoA Decarboxylase

Durdi Qujeq 1,2 * , Mohsen Tatar 2, Farideh Feizi 3, Hadi Parsian 1,2, Sohrab Halalkhor 2

1 Cellular and Molecular Biology Research Center, Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, IR Iran
2 Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, IR Iran
3 Department of Anatomical Sciences, Faculty of Medicine, Babol University of Medical Sciences, Babol, IR Iran
*Corresponding author: Durdi Qujeq, Cellular and Molecular Biology Research Center, Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, IR Iran. Tel: +98-1112229591-5, Fax: +98-1112226109, Email: d.qujeq@mubabol.ac.ir

Abstract

Background: The malonyl-CoA decarboxylase (MCD, EC.4.1.1.9) enzyme regulates malonyl-CoA levels. The effect of aerial parts extracts of Urtica dioica (UD) on MCD is poorly understood. Urtica dioica (UD) on MCD is poorly understood.

Objectives: The present experiment was undertaken to evaluate the effect of UD aerial parts extracts on MCD level.

Materials and Methods: In this experimental study, two groups of rats were used: normal and hyperglycemic group. Then UD aerial parts extracts (5 mg /500 μL) administrated to the hyperglycemic group of rats and finally, the MCD and insulin levels were measured in both groups.

Results: Interestingly, we observed that the UD aerial parts extracts powder caused a significant (P < 0.05) increase in insulin level during the experiment, from the base level of 0.36 ± 0.07 μg/L to the peak value of 0.52 ± 0.15 μg/L. Also, it caused a significant (P < 0.05) decrease in MCD level, from the base level of 29.68 ± 1.29 pg/mL to the bottom value of 22.12 ± 2.41 pg/mL.

Conclusions: The results of the present study indicate that UD aerial part extracts would decrease MCD level in hyperglycemic rats.

Keywords: Urtica dioica, Malonyl Coenzyme A Decarboxylase, Streptozotocin
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