Submitted: 02 Nov 2014
Revision: 25 Nov 2014
Accepted: 01 Feb 2015
ePublished: 21 Mar 2015
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Avicenna J Med Biochem. 2015;3(1): 2.
doi: 10.17795/ajmb-25084
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Research Article

The Association Between Matrix Metalloproteinase-7 A-181G Polymorphism and the Risk of Relapsing-Remitting Multiple Sclerosis in Iranian Kurdish Patients from Kermanshah

Fatemeh Mohammadi 1, Ziba Rahimi 2, Zohreh Rahimi 2,3*

1 Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, IR Iran
2 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, IR Iran
3 Department of Biochemistry, Medical School, Kermanshah University of Medical Sciences, Kermanshah, IR Iran
*Corresponding author: Zohreh Rahimi, Medical Biology Research Center, Medical School, Kermanshah University of Medical Sciences, Daneshgah Avenue, P.O. Box: 67148-69914, Kermanshah, IR Iran. Tel: +98-8334274882, Fax: +98-8334276471, E-mail: zrahimi@kums.ac.ir, rahimizus@yahoo.com


Background: Multiple sclerosis (MS) is a common chronic genetic disease of the central nervous system. The relapsing-remitting-MS (RRMS) is the most common form of this disease. Matrix metalloproteinase-7 (MMP-7) is an important member of the MMP family, which degrades many extracellular matrix components. The common polymorphism of MMP-7 A-181G is associated with some diseases.
Objectives: The aim of the present study was to determine the influence of this polymorphism on the risk of RR-MS.

Materials and Methods: Eighty RR-MS patients and 80 healthy individuals as controls from the Kermanshah province were studied for MMP-7 A-181G polymorphism by using the PCR-RFLP method. Data were analyzed using the SPSS statistical software package version 16.0.

Results: In RR-MS patients the frequency of MMP-7 GG genotype was significantly (P = 0.028) higher compared to that of the controls. The presence of GG genotype increased the risk of RR-MS by 1.69 times [OR = 1.69 and 95% CI = 1.05- 2.72, P = 0.03]. The frequency of MMP-7 G allele in RR-MS patients was significantly higher (51.2%, P = 0.043) than that of the controls (40%). The presence of this allele increased the risk of RR-MS by 1.58 folds (P = 0.044).

Conclusions: Our findings indicate that the presence of G allele of MMP-7 A-181G polymorphism might increase the risk of RR-MS in our population.

Keywords: Matrix Metalloproteinase 7, Polymorphism, Genetic, Multiple Sclerosis Relapsing-Remitting
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