Logo-ajmb
Submitted: 30 May 2016
Revision: 13 Jul 2016
Accepted: 26 Jul 2016
ePublished: 31 Aug 2016
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Avicenna J Med Biochem. 2016;4(2): 11-39507.
doi: 10.17795/ajmb-39507
  Abstract View: 2199
  PDF Download: 1676
  Full Text View: 1267

Research Article

Cord Blood Butyrylcholinesterase Activities in Normal Pregnant and Preeclamptic Women

Simmi Kharb 1*, Prerna Panjeta 2, Vikram Kala 2, VS Ghalaut 1, Jyoti Bala 1, Smiti Nanda 1

1 Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India
2 BPS Government Medical College forWomen, Khanpur Kalan, Sonepat, India
*Corresponding Author: *Corresponding author: Simmi Kharb, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India. Tel: +91-9812016036, , Email: simmikh@gmail.com

Abstract

Background: Human placenta, a non-neural tissue, contains cholinergic system and high-affinity muscarinic receptors. The role of cholinesterases (CE) in trophoblast function and pregnancy is not clear.

Objectives: The present study aimed to analyze cholinesterase (CE) levels in cord blood in preeclamptic women.

Methods: In the present study, maternal and cord blood butyrylcholinesterase levels were analyzed in women with preeclampsia (n = 25) and compared to those of normotensive pregnant women (n = 25) and normal, non-pregnant healthy controls (n = 25) by a kinetic method (the new DGKC method) using the AutoAnalyzer.

Results: In the present study, maternal butyrylcholinesterase levels were lower in preeclamptics as compared to normotensive controls. Butyrylcholinesterase levels were lower in the cord blood of the babies of normotensives, amounting to 88.65% of the maternal levels. Cord blood butyrylcholinesterase levels were significantly lower in preeclamptic pregnant women as compared to normotensive pregnant women. On comparing these butyrylcholinesterase levels to the normal, non-pregnant control (Group III), it was observed that CE levels were significantly lower in both normotensive and preeclamptic women.

Conclusions: The findings of the present study indicate that butyrylcholinesterase levels are lower in preeclamptics and that this might be due to the loss of muscarinic cholinergic receptors that occurs in preeclampsia.

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 2199

Your browser does not support the canvas element.


PDF Download: 1676

Your browser does not support the canvas element.


Full Text View: 1267

Your browser does not support the canvas element.