Avicenna J Med Biochem. 2013;1(1):23-29.
Research Article
Serum
butyrylcholinesterase activity and phenotype associations with lipid
profile during various phases of menstrual cycle in young healthy women
with regular menses, a preliminary report
Asad Vaisi-Raygani 1,2 * , Heidar Tavilani 3, Hadiss Vaisi-Raygani 1, Zohreh Rahimi 2,4, Jamshid Karimi 5, Tayebeh Pourmotabbed 6
1 Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Molecular Diagnostic Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Urology & Nephrology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
4 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
5 Department of Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran
6 Department of Microbiology, Immunology, Biochemistry University of Tennessee Health Science Center, Memphis, TN, USA
Abstract
Objectives: In
this study the association of phenotypes and activity of
butyrylcholinesterase (BuChE) with serum level of lipid-lipoprotein and
apolipoproteins during various phases of menstrual-cycle was determined.
Methods: The
study population consisted of 22 healthy women aged 19–25 years with
regular menstrual cycles, 26–30 days in length. The serum levels of
lipids, apolipoproteins, and BuChE activity were determined during
menses (days 1-2 after the beginning of menstruations), follicular (days
7-8) and luteal (days 21-22) phases of the menstrual cycle.
Results: There
were significant differences in the level of serum BuChE activity
during three phases of the menstrual cycle (P=0.049). The activity of
serum BuChE was the highest during follicular phase (890 ± 292 IU/L),
the modest during the menses phase (831 ± 222 IU/L) and the lowest
during luteal phase (707 ±211 IU/L). We found a significant positive
correlation between BuChE activity with the levels of low density
lipoprotein cholesterol (LDL-C, r=0.34, P=0.038) in the follicular and
in the menses phase with LDL-C (r=0.4, P =0.025) and triacylglycerol
(r=0.47, P=0.033). In addition, carriers of the non-UU phenotypes
(non-wild type low BuChE activity) had significantly lower levels of
serum high density lipoprotein cholesterol (HDL-C) and apolipoprotein A1
(APOA1) compared to UU phenotype (usual or wild type) during menstrual
cycle.
Conclusion: Our
results demonstrate that serum BuChE activity elevates during menstrual
cycle. It is low during luteal phase and reaches to a high level in
follicular-phase. The lipid profiles are also affected by BuChE activity
throughout the menstrual-cycle in reproductive aged, regularly cycling
and young healthy women.
Keywords: Butyrylcholinesterase; Lipids; Lipoproteins; Menstrual cycle