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Submitted: 04 Oct 2020
Revision: 03 Nov 2020
Accepted: 08 Nov 2020
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  Abstract View: 20

Research Article

Comparison of antioxidant and antiacetylcholinesterase activities in vitro and in vivo of different extracts of Tunisia Maclura pomifera Raf. (Schneid) fruits

Mohamed Mendili ORCID logo, Mohamed Ali Smach ORCID logo, Nedaa Husein ORCID logo, Ayda Khadhri* ORCID logo

Abstract

Background: Maclura pomifera a member of Moraceae family, is a tropical plant with ethnobotanical uses.
Objectives: The present study aimed to evaluate bioactive compounds, antioxidants and acetylcholinesterase inhibitory activities in vitro and in vivo.
Methods: Organic extracts in different polarities (chloroform, ethyl acetate, and acetone) were extracted from different parts of the fruit of M. pomifera (exocarp, mesocarp and pips). Phenolic content, antioxidant activity and anti-acetylcholinesterase activity were determined. The anti-amnesic effects of Ethyl acetate extract of the exocarp of M. pomifera were measured in galactose-induced memory deficits mice by the Y maze. The levels of biomarkers and acetylcholinesterase activity were determined in brain tissues.
Results: The obtained results showed that the ethyl acetate extract of exocarp contains the highest content of flavonoids and polyphenols 22.3 mg quercetin equivalents per g of dry weight and 718.6 mg gallic acid equivalents per g of dry weight. The antioxidant activities evaluating highlighted that the ethyl acetate extract of exocarp was the most active. The study of the acetylcholinesterase inhibitory power demonstrated that the greatest inhibitory activity is that of the ethyl acetate extract of the exocarp. It turns out that the ethyl acetate extract from the exocarp ameliorated cognitive performance and reversed the oxidative damage as compared to galactose group.
Conclusion: Thus, the study suggests that M. pomifera fruit is a better source of natural antioxidants, which might help prevent oxidative stress-related damage and memory impairment such as in Alzheimer's disease.
Keywords: Maclura pomifera, phenolic content, antioxidant activity, acetylcholinesterase inhibition, in vivo, in vitro,
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