Submitted: 28 Oct 2020
Accepted: 30 Oct 2020
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  Abstract View: 25

Research Article

Kiwifruit supplementation increases the activity of paraoxonase enzyme and decreases oxidized LDL in high-fat diet fed hamsters

Narjes Rezaei, Zahra Zaherijamil, Shirin Moradkhani, Massoud Saidijam*, Iraj khodadadi, Ebrahim Abbasi Oshaghi, Heidar Tayebinia* ORCID logo


Background: It has been shown that kiwifruit elevates serum high-density lipoprotein cholesterol (HDL-C) levels and exhibits beneficial effects on human health due to it’santioxidant potential.
Objective: This study aimed to investigate the impact of kiwifruit on the activity of the paraoxonase 1 (PON1) enzyme, a main antioxidant enzyme in HDL functionality, in a high-fat diet (HFD).
Methods: Forty-two male Syrian hamsters were divided into six groups as follows: hamsters which received a normal diet (control normal group), hamsters which received a regular diet supplemented with kiwifruit at concentrations of (1.86 g/kg and 3.73 g/kg), hamsters which received a high fat diet(HFD) that comprised of 15% butterfat + 0.05% cholesterol (control high-fat group) and hamsters which received a HFD supplemented with kiwifruit at concentrations of (1.86 and 3.73 g/kg) for 8 weeks.
Results: The results showed that supplementation of kiwifruit to the HFD increased the levels of HDL-C and remarkably reduced the concentrations of oxidized low-density lipoprotein (ox-LDL) and MDA compared with the control-HF group. Also, the paraoxonase activity of PON1 significantly increased in HFD supplemented with kiwi fruit (1.86 g/kg ) and arylesterase activity (ARE) was increased in all of the treated groups when compared with untreated groups.
Conclusion: Our findings suggest that kiwifruit can improve the lipid profile and prevent oxidative stress-induced by lipid peroxidation in hamsters receiving HFD, thereby increasing the arylesterase and paraoxonase activities of PON1.
Keywords: Kiwifruit, Paraoxonase 1, Liver tissue, High-density lipoprotein, High-fat diet,
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Abstract View: 25

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