Submitted: 05 Apr 2022
Revision: 14 Sep 2022
Accepted: 18 Sep 2022
ePublished: 19 Dec 2022
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Avicenna J Med Biochem. 2022;10(2): 84-89.
doi: 10.34172/ajmb.2022.2358
  Abstract View: 102
  PDF Download: 76

Original Article

Angiotensinogen Gene M235T and T174M Polymorphisms in Diabetic Nephropathy in a Bangladeshi Population

Md. Mizanur Rahman 1,2* ORCID logo, Shahidul Islam Salim 3, Imran Khan 4, Khondoker Moazzem Hossain 2, Liaquat Ali 5,6, Zahid Hassan 7

1 Department of Medicine, Division of Nephrology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, T6G2G3, Canada
2 Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh
3 Department of Nephrology, Bangabandhu Sheikh Mujib Medical University, Dhaka-1000, Bangladesh
4 Incepta Vaccines Limited, Dhaka, Bangladesh
5 Department of Biochemistry & Cell Biology, Bangladesh University of Health Sciences, 125/1 Darus Salam, Mirpur-1, Dhaka-1216, Bangladesh
6 Department of Research & Development, Pothikrit Institute of Health Studies, Dhaka, Bangladesh
7 Department of Physiology & Molecular Biology, Bangladesh University of Health Sciences, 125/1 Darus Salam, Mirpur-1, Dhaka-1216, Bangladesh
*Corresponding Author: Corresponding author: Md. Mizanur Rahman, Email: , Email: mmr1@ualberta.ca


Background: Marker gene polymorphisms linked with the renin-angiotensin-aldosterone system (RAAS) have been broadly studied in diabetic nephropathy (DN) patients considering that RAAS is a potential drug target to slow down kidney disease progression.

Objectives: The aim of the present study was to determine the link between M235T and T174M variants of angiotensinogen (AGT) gene and DN.

Methods: A total of 93 patients with DN, mean age of 56±8 years, systolic blood pressure (SBP) of 141±14, and diastolic blood pressure (DBP) of 84±7 mm Hg (mean±SD) were investigated, among whom 59 patients had a family history of type 2 diabetes mellitus. A total of 96 healthy subjects served as the control group with no family history of diabetic nephropathy (FHDN) and type 2 diabetes mellitus, a mean age of 47±10 years, SBP of 126±11, and DBP of 76±6 mm Hg. PCR–restriction fragment length polymorphism was employed for genotyping M235T and T174M molecular variants.

Results: Genotype frequencies of the variants M235T (χ2=2.038, P=0.361) and T174M (χ2=2.952, P=0.229) did not show any statistically significant association with type 2 diabetic nephropathy (T2DN) compared to the control. Based on FHDN and family history of diabetes mellitus (FHDM), the frequency of genotypes of M235T marker (P=0.360) in FHDN, and (P=0.886) FHDM; T174M marker (P=0.641) in FHDN, and (P=0.425) FHDM also did not show any statistically significant association with T2DN compared to the controls.

Conclusion: M235T and T174M variants were not associated with DN in a Bangladeshi population.

Please cite this article as follows: Rahman MM, Salim SI, Khan I, Hossain KM, Ali L, Hassan Z. Angiotensinogen gene m235t and t174m polymorphisms in diabetic nephropathy in a bangladeshi population. Avicenna J Med Biochem. 2022; 10(2):84-89. doi:10.34172/ ajmb.2022.2358
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