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Submitted: 01 Nov 2022
Revision: 22 Jan 2023
Accepted: 01 Feb 2023
ePublished: 18 Mar 2023
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Avicenna J Med Biochem. 2023;11(1): 11-18.
doi: 10.34172/ajmb.2023.2398
  Abstract View: 269
  PDF Download: 205

Original Article

Phenolic Compounds and Skin Permeability: An In Silico Investigation

Majdi Hammami ORCID logo, Emna Chaabani ORCID logo, Walid Yeddes ORCID logo, Wissem Aidi Wannes* ORCID logo, Soumaya Bourgou ORCID logo

1 Laboratory of Medicinal and Aromatic Plants, Biotechnology Center of Borj-Cedria,BP 901, 2050, Hammam-Lif, Tunisia
*Corresponding Author: Wissem Aidi Wannes, Email: aidiwissem@yahoo.fr

Abstract

Background: The skin is the largest organ of the body and provides the main barrier between the internal and external environment. Assessment of skin permeability is of critical importance for understanding and predicting in vivo efficacy and bioavailability of bioactive phenolic compounds.

Objectives: This study investigated the relationship between skin permeability and phenolic compounds using in silico methods.

Methods: Screening of skin permeability was performed on 475 randomly selected phenolic compounds. Molecules were expressed in SMILE format downloaded from Phenol-Explorer Database (version 3.6, 2016). Then, their skin permeability was determined by the linear model of the quantitative structure-activity relationship (QSAR). The obtained results were investigated for normal distribution and correlation with pharmacological properties.

Results: Our investigation showed that ferulate hydroxycinnamic acid derivatives were the most important phenolic subclass with a permeability of -1.65 cm/s. The relationship between permeability and lipophilicity, water solubility, synthetic accessibility, and bioavailability was evaluated. The statistical analysis revealed that the highest skin permeability was associated with three parameters: the topological polar surface area (TPSA), molecular weight, and lipophilicity (iLog P).

Conclusion: The cutaneous permeability depended on several chemical parameters of the molecule used. The classification of phenolic compounds according to their structures proved a wide variability in this permeability.


Please cite this article as follows: Hammami M, Chaabani E, Yeddes W, Aidi Wannes W, Bourgou S. Phenolic compounds and skin permeability: An in silico investigation. Avicenna J Med Biochem. 2023; 11(1):11-18. doi:10.34172/ajmb.2023.2398
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