Submitted: 21 Feb 2023
Revision: 27 Mar 2023
Accepted: 05 Apr 2023
ePublished: 28 Jun 2023
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Avicenna J Med Biochem. 2023;11(1): 41-45.
doi: 10.34172/ajmb.2023.2430
  Abstract View: 308
  PDF Download: 243

Original Article

The Effects of Lead on Some Markers of Liver and Kidney Functions of Lead Recycling Factory Workers are Mediated Through Increased Oxidative Stress

Christian Ejike Onah 1* ORCID logo, Chinwemma Florence Onah 2, Stephen Monday Suru 3, Chinedu Michael Olisah 4, Alfred Friday Ehiaghe 1, Chukwuemeka Emmanuel Ogbodo 1 ORCID logo, Wuraola Serah Nnaemeka 3, Ukamaka Ann Ijeomah 5, Chukwuemeka Samuel Meludu 3, Chudi Emmanuel Dioka 6

1 Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka, Nigeria
2 Department of Nursing Services, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria
3 Department of Human Biochemistry, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Awka, Nigeria
4 Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Chukwuemeka Odimegwu Ojukwu University, Uli, Nigeria
5 Department of Biochemistry, Faculty of Natural and Applied Sciences, Nasarawa State University Keffi, Nigeria
6 Department of Chemical Pathology, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria
*Corresponding Author: Christian Ejike Onah, Email: ce.onah@unizik.edu.ng


Background: Lead is a highly toxic metal of great public health importance.

Objectives: This cross-sectional study was conducted to evaluate the kidney and liver function status and the markers of oxidative stress among lead recycling factory workers in Anambra State, Nigeria.

Methods: A total of 82 subjects (41 experimental and 41 control subjects) aged 20-60 years were recruited in this study. Lead levels in whole blood were measured using atomic absorption spectrometry. Serum malondialdehyde (MDA) and uric acid levels as well as the activities of glutathione S-transferase (GST), alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and γ-glutamyltransferase (γ-GT) were measured using the spectrophotometric method. Superoxide dismutase (SOD) and catalase activities were determined using colorimetric method and Berthelot’s and Jaffe slot methods were used to measure urea and creatinine levels, respectively.

Results: The mean activities of SOD, GST, and catalase as well as estimated glomerular filtration rate (eGFR) were significantly lower in lead recycling workers compared with control group (P<0.05), whereas the mean activities of ALT, AST, ALP, and γ-GT, as well as blood lead, MDA, urea, creatinine, and uric acid levels significantly increased in lead recycling workers (P<0.05). Furthermore, blood lead level was found positively correlated with MDA and creatinine levels but negatively with eGFR and GST levels (P<0.05). MDA level showed positive and negative correlations with creatinine and eGFR (P<0.05), respectively.

Conclusion: This study revealed significant alterations in the levels of some biochemical and oxidative stress parameters in liver and kidney in lead recycling factory workers and showed a possible link between oxidative stress and the toxic effects of lead on the kidney and liver.

Please cite this article as follows: Onah CE, Onah CF, Suru SM, Olisah MC, Ehiaghe FA, Ogbodo EC, et al. The effects of lead on some markers of kidney, liver, and cardiovascular system of lead recycling factory workers mediated through increased oxidative stress. Avicenna J Med Biochem. 2023; 11(1):41-45. doi:10.34172/ajmb.2023.2430
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