Submitted: 06 May 2023
Revision: 13 Jul 2023
Accepted: 13 Jul 2023
ePublished: 22 Aug 2023
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Avicenna J Med Biochem. 2023;11(2): 117-122.
doi: 10.34172/ajmb.2438
  Abstract View: 271
  PDF Download: 153

Original Article

Effects of Methanolic Extract of Aloe vera on C-Reactive Protein and White Blood Cell Count of Wistar Rats With Inflammation

Arinze Favour Anyiam 1* ORCID logo, Emmanuel Anyachukwu Irondi 2 ORCID logo, Ejeatuluchukwu Obi 3 ORCID logo, Onyinye Cecilia Arinze-Anyiam 1 ORCID logo, Pius Omoruyi Omosigho 4 ORCID logo, Musa Abidemi Muhibi 4 ORCID logo, Ayodele Olusola Ilesanmi 5 ORCID logo, Okelola Odunayo Oluwatimilehin 5, Blessing Okezie 6 ORCID logo

1 Department of Medical Laboratory Science, Faculty of Basic Medical and Health Sciences, Thomas Adewumi University, Oko, P. M. B. 1030, Kwara State, Nigeria
2 Department of Medical Biochemistry and Pharmacology, Faculty of Pure and Applied Sciences, Kwara State University, Malete, P.M. B. 1530, Kwara State, Nigeria
3 Department of Pharmacology and Therapeutics, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State, Nigeria
4 Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, Edo State University, Uzairue, Edo State, Nigeria
5 Department of Medical Laboratory Science, Faculty of Pure and Applied Sciences, Kwara State University, Malete, P.M. B. 1530, Kwara State, Nigeria
6 Department of Medical Laboratory Science, Achievers University, Owo, Ondo State, Nigeria
*Corresponding Author: Arinze Favour Anyiam, Email: arinzeanyiam@gmail.com, Email: arinzeanyiam@gmail.com


Background: It has been known for centuries that plants and plant-derived chemicals are useful in treating diseases, with Aloe vera being one of the biologically active plants. A significant role is played by the C-reactive protein (CRP) in many inflammatory conditions, while leukocytes play an integral role in the response of the immune system to infectious diseases.

Objectives: This study explored the potential anti-inflammatory effects of Aloe vera methanolic extract on the total white blood cell (TWBC) count and CRP levels in Wistar rats received formalin.

Methods: A total of 25 Wistar rats were divided into five groups (A to E), with group A serving as the control and the other groups receiving formalin to induce inflammation, followed by increasing doses of Aloe vera extract. The CRP level was measured using an enzyme-linked immunosorbent assay (ELISA) kit, and the TWBC count was determined using a Sysmex haematology autoanalyzer.

Results: Research findings showed that 200 mg of Aloe vera methanolic extract effectively reduced the CRP level (0.056±0.0027) (P=0.04), while 600 mg of the extract significantly increased the TWBC count (13.920±4.757) (P=0.03).

Conclusion: These findings suggest that Aloe vera extract may be an effective natural supplement for improving the immune system function and reducing inflammation in the body. However, further research is needed to fully understand the underlying mechanisms for these effects and to determine the optimal doses and potential side effects.

Please cite this article as follows: Favour Anyiam A, Anyachukwu Irondi E, Obi E, Cecilia Arinze-Anyiam O, Omoruyi Omosigho P, Abidemi Muhibi M, et al. Effects of methanolic extract of Aloe vera on C-reactive protein and white blood cell count of Wistar rats with inflammation. Avicenna J Med Biochem. 2023; 11(2):117-122. doi:10.34172/ajmb.2438
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