Submitted: 18 Jun 2023
Revision: 27 Nov 2023
Accepted: 18 Dec 2023
ePublished: 29 Dec 2023
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Avicenna J Med Biochem. 2023;11(2): 146-150.
doi: 10.34172/ajmb.2444
  Abstract View: 204
  PDF Download: 150

Original Article

Comparison of Follicular Fluid Glycosaminoglycan and Hydroxyproline Concentration in Women with Polycystic Ovary Syndrome with Healthy Women

Kiana Kimiaei Asadi 1 ORCID logo, Kimia Amiri 1, Hadi Ghasemi 2 ORCID logo, Iraj Amiri 3* ORCID logo

1 School of Medicine, Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3 Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan Iran
*Corresponding Author: Iraj Amiri, Email: amiri44@yahoo.com, Email: amiri44@yahoo.com


Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women of childbearing age. As a complex structure, the extracellular matrix (ECM) and its components, including glycosaminoglycans (GAGs) and collagens, are highly affected by hormonal alterations.

Objectives: This study aimed to evaluate the level of GAG and hydroxyproline in the follicular fluid (FF) of women with PCOS.

Methods: Overall, 62 women referring to Fatemieh Hospital Infertility Center in Hamadan were evaluated in this study. FF samples were taken from 31 women with PCOS during ovarian puncture and 31 healthy women. Oocytes were evaluated in the different stages of maturation, namely, metaphase II (MII) and germinal vesicle (GV). Commercially available kits were used to measure the levels of glycosaminoglycans and hydroxyproline.

Results: The results of the present study showed that the count of oocytes in women with PCOS was significantly higher than that in healthy women. Evaluating GAG and hydroxyproline levels indicated that their levels were meaningfully higher in the FF of women with PCOS.

Conclusion: In general, the results of this study suggested that ECM changes in PCOS followed by alterations in the levels of GAGs and hydroxyproline may lead to an increase in the level of GAG and hydroxyproline in the FF. The evaluation of these markers may be the subject of further studies.

Please cite this article as follows: Kimiaei Asadi K, Amiri K, Ghasemi H, Amiri I. Comparison of follicular fluid glycosaminoglycan and hydroxyproline concentration in women with polycystic ovary syndrome with healthy women. Avicenna J Med Biochem. 2023; 11(2):146-150. doi:10.34172/ajmb.2444
First Name
Last Name
Email Address
Security code

Abstract View: 205

Your browser does not support the canvas element.

PDF Download: 150

Your browser does not support the canvas element.