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Submitted: 11 Jun 2017
Accepted: 01 Dec 2017
ePublished: 23 Dec 2017
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Avicenna J Med Biochem. 2017;5(2): 70-75.
doi: 10.15171/ajmb.2017.13
  Abstract View: 1492
  PDF Download: 1144

Research Article

Improved Glucose and IL-6 by Aerobic Training Despite no Change in Insulin and Insulin Resistance in Obese Women

Mojtaba Eizadi 1* ORCID logo, Mohammad Taghi Goodarzi 2, Zahra Mirakhori 3, Ashraf Amini 3

1 Assistant Professor of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, Iran
2 Professor of Clinical Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran
3 Assistant Professor of Physical Education and Sport Sciences, Amirkabir University of Technology, Tehran, Iran
*Corresponding Author: Corresponding author: Mojtaba Eizadi, Tel: 09193551960; Email:, Email: izadimojtaba2006@yahoo.com

Abstract

Background: Regular physical activity is recognized as a non-pharmacological treatment of inflammation and glycemic profile.

Objectives: This exercise aimed to determine the effect of aerobic training on serum interleukin-6 (IL-6), glucose and insulin resistance in obese females.

Patients and Methods: Thirty-two middle-aged obese women (body mass index [BMI], 32 ± 3 kg/m2) aged 35 to 45 years were randomly assigned to exercise (aerobic training, n=16) and control (n=16) groups. Exercise subjects were completed a 12 weeks aerobic training program as 3 sessions per week at 60%-80% of HRmax and control subjects received no training. Pre- and post-training of fasting serum IL-6, insulin, insulin resistance, and glucose concentration were measured and compared between 2 groups. Results were compared using t test at a significance level of P<0.05.

Results: Exercise group obtained significant decreases in BMI, body fat %, and abdominal obesity as well as the concentrations of serum IL-6 and fasting glucose (P<0.05). No significant difference was observed between pre- and post-training of insulin and insulin resistance in the exercise group (P >0.05). There were no alterations in these variables in the control group (P>0.05).

Conclusions: These data suggest that aerobic training may improve glycemic profile in absence of change in insulin resistance of women with abdominal obesity

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