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Submitted: 02 Oct 2015
Revision: 18 Oct 2015
Accepted: 27 Oct 2015
ePublished: 16 Jan 2016
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Avicenna J Med Biochem. 2016;4(1): 6-33474.
doi: 10.17795/ajmb-33474
  Abstract View: 2009
  PDF Download: 1173
  Full Text View: 1517

Research Article

Association Between Migraine and Diabetes in Pregnancy

Syeda Zain 1, Syed Farrukh Mustafa 2, Hamza Abdur Rahim Khan 2, Muhammad Faraz Raghib 2, Syeda Sadia Fatima 3*

1 Department of Pharmacology, United Medical and Dental College, Karachi, Pakistan
2 Medical College, Aga Khan University, Karachi, Pakistan
3 Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
*Corresponding Author: *Corresponding author: Syeda Sadia Fatima, Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan, , Email: sadia.fatima@aku.edu

Abstract

Background: Migraine ranks as the eighth most disabling condition and one of the most common causes of headache in Pakistan.

Objectives: In this study, we aimed to determine the association between migraine and diabetes in pregnant women.

Patients and Methods: This cross-sectional study recruited 498 pregnant women, grouped into pregnant without diabetes (n = 300) and pregnant with diabetes (n = 198) according to the International Association of the Diabetes and Pregnancy Study criteria. Seventy-five women with known migraine were also recruited as positive controls. After confirming that the study subjects had headache at least once a month, the researcher filled out a comprehensive form based on the International Classification of Headache Disorders version II. Migraine disability score was used to assess severity. Fasting blood glucose levels were measured by using the enzymatic method. Data were presented as meanSD and frequencies, where applicable. Chi-square test and Spearman correlation test were performed. A P value of <0.05 was considered significant.

Results: The headache prevalence during pregnancy was 69% in the women with diabetes and 64% in the women without diabetes. A positive unilateral distribution was observed in 51% of the cases and 36.3% of the controls (P< 0.01). However, 94.7% of the pregnant cohort reported not having experienced aura. Of the pregnant women with diabetes, 19% fell within the mild to moderate disability score as compared with the 10.3% of the pregnant women without diabetes (P < 0.01). High fasting blood glucose levels showed a significant association with headache scores (r = 0.144; P < 0.01).

Conclusions: Headaches, particularly migraine without aura, are a common occurrence in pregnancy in our population. Migraine severity is positively associated with high blood glucose levels.

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Abstract View: 2009

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PDF Download: 1173

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Full Text View: 1517

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