Hamadan University of Medical Sciences Avicenna Journal of Medical Biochemistry 2345-4113 13 1 2025 10 31 Effect of Barg-e-Sehjana (Moringa oleifera Lam.) on Hypothyroidism: A Randomized Single Blind Placebo Controlled Clinical Study 10 17 10.34172/ajmb.2622 EN Shabnam Ansari https://orcid.org/0000-0002-3933-4388 Mohd Aleemuddin Quamri https://orcid.org/0000-0002-2695-2582 Journal Article 10.34172/ajmb.2622 2025 07 16 2025 09 24 Background: Hypothyroidism is a widely prevalent endocrine disorder that can result in multisystem dysfunction and end-organ damage if left untreated. In conventional medicine, levothyroxine remains the standard therapy; however, it may be associated with adverse effects such as iatrogenic hyperthyroidism, osteoporosis, increased risk of fracture, and atrial fibrillation. Objectives: The present study was designed to evaluate the therapeutic potential of Moringa oleifera Lam. (Barg-e-Sehjana) in the management of hypothyroidism. Methods: In this randomized single blind placebo controlled clinical study, a total of 52 patients diagnosed with hypothyroidism were randomly assigned into two groups: test (n=26) and control (n=26). The test group received M. oleifera Lam. powder at a dose of 3 g/day, while the control group received placebo at a dose of 3 g/day with water once a day after breakfast for 45 days. Out of 52 patients, 46 patients completed the study, and their serum TSH levels were determined at baseline and at the end of the trial as a study outcome. Results: In the test group, the mean baseline TSH level decreased from 10.22±3.72 µIU/mL to 6.83±2.85 µIU/mL. The difference was 3.39, with a P value of <0.001 and Cohen’s d of 3.9, indicating a large effect size with a 95% confidence interval. In contrast, the control group exhibited a less significant reduction from 8.21±3.22 µIU/mL to 6.38±4.84 µIU/mL with a difference of 1.83 (P<0.10). Conclusion: The findings of the present study demonstrate that the daily administration of 3 g of M. oleifera Lam. powder is effective in reducing elevated levels of TSH and improving thyroid function in patients with hypothyroidism.