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Submitted: 05 Oct 2020
Accepted: 11 Nov 2020
ePublished: 30 Dec 2020
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Avicenna J Med Biochem. 2020;8(2): 128-132.
doi: 10.34172/ajmb.2020.18
  Abstract View: 67
  PDF Download: 7

Brief Report

Comparison of Serum Iron, Zinc, and Selenium Levels in Premenopausal and Postmenopausal Women in Ekpoma, Nigeria: A Descriptive Study

Oloruntoba O. Festus 1 ORCID logo, Solomon O. Agbebaku 2, Blessing O. Idonije 3, Olarewaju M. Oluba 4* ORCID logo

1 Department of Medical Laboratory Science, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria
2 Department of Chemical Pathology, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria
3 Department of Medical Biochemistry, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria
4 Department of Biochemistry, Food Safety & Toxicology Research Unit, College of Pure and Applied Sciences, Landmark University, Omu-Aran, Kwara State, Nigeria
*Corresponding author: Olarewaju M. Oluba, Department of Biochemistry, Food Safety & Toxicology Research Unit, College of Pure and Applied Sciences, Landmark University, OmuAran, Kwara State, Nigeria Tel: +2347030496639, Email: oluba.olarewaju@lmu. edu.ng; olubamike2000@yahoo.co.uk

Abstract

Background: Estrogen deficiency following menopause creates an imbalance in plasma micronutrient resulting in several degenerative pathological conditions, including hypertension, cardiovascular disease, osteoporosis, etc.

Objectives: The present study was designed to compare zinc (Zn), iron (Fe), and selenium (Se) concentrations between premenopausal and postmenopausal women.

Methods: In this descriptive study a total of 200 participants were classified into two groups of postmenopausal (age range: 46-75 years, served as experimental) and premenopausal (age range: 30-45 years, served as control). Each group consisted of 100 subjects. After obtaining informed consent from all participants, blood samples were collected from the antecubital fossa vein of each participant by venipuncture. The concentrations of Fe, Zn, and Se in each blood sample were determined using Atomic Absorption Spectrophotometer.

Results: No significant difference (P>0.05) was observed in serum Fe (114.24 ± 26.79 µg/dL), Zn (83.11 ± 20.45 µg/dL), and Se (41.99 ± 9.78 µg/dL) levels between the control and experimental groups. However, serum Fe and Zn showed progressive significant (P=0.04, 0.03, respectively) increase with increasing postmenopausal age. Conversely, serum Se concentration decreased significantly (P=0.03) with increasing menopausal age.

Conclusion: Although no significant difference was observed in serum levels of Fe, Zn, and Se between pre- and post-menopausal women, the progressive significant increase in the serum Fe and Zn levels as well as significant decrease in serum Se level with advancing post-menopausal age portend a great risk.

Keywords: Trace mineral, Menopause, Postmenopausal women,
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