Submitted: 02 Aug 2021
Revision: 03 Sep 2021
Accepted: 07 Sep 2021
ePublished: 29 Dec 2021
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Avicenna J Med Biochem. 2021;9: 72-82.
doi: 10.34172/ajmb.2021.13
  Abstract View: 186
  PDF Download: 88

Research Article

Standardized Extract of Costus Afer Ker. Gawl leaves Modulates Reproductive Toxicity Caused by FructoseStreptozotocin Administration in Type-2 Diabetic Rats Model

Tope Gafar Atere 1* ORCID logo, Oluseyi Adeboye Akinloye 2, Regina Ngozi Ugbaja 2, David Ajiboye Ojo 3

1 Department of Medical Biochemistry, College of Health Sciences, Osun State University, Osogbo, Nigeria
2 Department of Biochemistry, College of Bioscience, Federal University of Agriculture, Abeokuta, Nigeria
3 Department of Microbiology, College of Bioscience, Federal University of Agriculture, Abeokuta, Nigeria
*Corresponding Author: Email: tope.atere@uniosun.edu.ng


Background: Co-administration of streptozotocin and fructose is believed to induce type 2 diabetes as well as to cause reproductive toxicity and testicular damage via increasing oxidative stress in rats.

Objectives: In this study, the potential protective effect of Costus afer leaves methanol extract (CAME) on andrological parameters and pituitary-gonadal axis hormones of type 2 diabetes (T2D) in rats treated with streptozotocin and fructose was investigated.

Methods: A total of 35 rats were divided into five groups, each including seven rats. Group 1 received normal saline, whereas T2D was induced in rats from groups 2, 3, 4, and 5. Group 2 served as diabetic control; while groups 3, 4, and 5 were treated orally with 12 mg/kg body weight (BW) of metformin as well as 100 and 200 BW of CAME, respectively, for 4 weeks. Hypothalamic–pituitary–gonadal responses, andrological parameters, DNA fragmentation, and oxidative stress parameters of the reproductive organs were examined in all treatment groups.

Results: Administration of CAME reduced the degenerative changes in testes, epididymis and improved pituitary-gonadal axis hormone concentrations, and sperm morphology occasioned by the treatments.

Conclusion: It was concluded that the administration of CAME ameliorated reproductive abnormalities in T2D rat models treated with streptozotocin-fructose administration.

Keywords: Costus afer, Andrological parameters, Diabetes mellitus, Oxidative stress, Sperm analysis,
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