Submitted: 05 Oct 2020
Revision: 10 Nov 2020
Accepted: 11 Nov 2020
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  Abstract View: 25

Brief Report

Comparative Study on Serum Iron, Zinc and Selenium Levels in Premenopausal and Postmenopausal Women in Ekpoma, Nigeria: A Descriptive Study

Oloruntoba O Festud ORCID logo, Solomon O Agbebaku, Blessing O. Idonije, Olarewaju Michael Oluba* ORCID logo


Aim: Estrogen deficiency following menopause creates an imbalance in plasma micronutrient resulting in several degenerative pathological conditions including hypertension, cardiovascular disease, osteoporosis, etc. The present study was designed to compare Zn, Fe, and Se concentrations between premenopausal and postmenopausal women.
Methods: A descriptive study comprising of a total of two hundred (100) subjects consisting of 100 postmenopausal (aged 46-75 years, served as experimental) and 100 premenopausal (aged 30-45 years, served as control) women. Following informed consent, blood sample was collected from the anti-cubital fossa vein of each participant by venipuncture first thing in the morning before the commencement of daily activity into plain sample bottles. The concentrations of Fe, Zn and Se in each blood sample was determined using Atomic Absorption Spectrophotometer.
Results: No significant difference (p > 0.05) was observed in serum Fe (114.24 ± 26.79 µg/dL), Zn (83.11 ± 20.45 µg/dL) and Se (41.99 ± 9.78 µg/dL) levels between control and experimental groups. However, serum Fe and Zn showed progressive significant (p = 0.04, 0.03, respectively) increases with increasing postmenopausal age. Conversely, serum Se concentration decreased significantly (p = 0.03) with increasing menopausal age in women.
Conclusion: Though no remarkable difference was observed in serum Fe, Zn, and Se between pre- and post-menopausal women in this study, the progressive significant increase in the serum Fe and Zn levels as well as significant decrease in serum Se level with advancing post-menopausal age portends a great risk.
Keywords: Trace mineral, Menopause, Post-menopausal women,
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Abstract View: 25

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