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Submitted: 17 Nov 2021
Revision: 24 Apr 2022
Accepted: 02 May 2022
ePublished: 12 Dec 2022
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Avicenna J Med Biochem. 2022;10(2): 101-107.
doi: 10.34172/ajmb.2022.2321
  Abstract View: 350
  PDF Download: 239

Original Article

Cardiovascular Property of Resistance Training With an Emphasis on PI3K/AKT1 Genes Expression in Type 2 Diabetic Rats

Mohammad Dastyar 1 ORCID logo, Mojtaba Eizadi 2* ORCID logo, Mania Roozbayani 1 ORCID logo

1 Department of Exercise Physiology, Borujerd Branch, Islamic Azad University, Borujerd, Iran
2 Department of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, Iran
*Corresponding Author: Corresponding author: Mojtaba Eizadi, Email: , Email: izadimojtaba2006@yahoo.com

Abstract

Background: The potential role of exercise in physiological cardiac hypertrophy is rooted in both hormonal and genetic components.

Objectives: The aim of this study was to determine the impact of resistance exercise on the expression of PI3K and AKT1 in cardiac tissue of type 2 diabetes (T2D) rats and their physiological cardiac hypertrophy.

Methods: First, 21 male Wistar rats (220±20 g) were obese with 6-week high-fat diet (HFD) and were randomly assigned into non-diabetes, control T2D, and exercise diabetes groups. After inducing obesity, T2D was induced by intraperitoneal injection of streptozotocin (25 mg/kg) for diabetes groups. Rats in the exercise group completed a 6-week resistance exercise program, 5 sessions per week. PI3K/AKT1 expression and the weight ratio of left ventricular to heart, heart to body, and left ventricular to body were compared by analysis of variance (ANOVA) between groups.

Results: In response to the induction of diabetes, the expression of PI3K/AKT1 in heart tissue decreased significantly compared to that of non-diabetic rats (P=0.001 and P=0.001, respectively). Further, resistance training led to a significant increase in PI3K expression (P=0.028) and AKT1 (P=0.032) and the weight ratio of left ventricular to heart (P=0.001), heart to the body (P=0.001), and left ventricular to the body (P=0.001) compared to control diabetic rats.

Conclusion: Resistance training is associated with physiological cardiac hypertrophy in diabetic rats, and this improvement may be attributed to the PI3K/AKT1 signaling pathway.


Please cite this article as follows: Dastyar M, Eizadi M, Roozbayani M. Cardiovascular property of resistance training with an emphasis on PI3K/AKT1 genes expression in type 2 diabetic rats. Avicenna J Med Biochem. 2022; 10(2):101-107. doi:10.34172/ajmb.2022.2321
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