Submitted: 18 Aug 2022
Revision: 19 Sep 2022
Accepted: 20 Sep 2022
ePublished: 12 Nov 2022
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Avicenna J Med Biochem. 2022;10(2): 128-134.
doi: 10.34172/ajmb.2022.2383
  Abstract View: 570
  PDF Download: 320

Original Article

Evaluation of Acute and Subacute Toxicity of Fumaria officinalis Alkaloids in Mice

Sonia Yahiaoui 1, Sabiha Khamtache-Abderrahim 2, Amar Otmani 1, Mostapha Bachir-bey 1* ORCID logo, Djamel-Edine Kati 1, Michelle Lequart-Pillon 3, Eric Gontier 3, Fadila Maiza-Benabdesselam 3

1 Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, 06000 Bejaia, Algérie
2 Laboratoire de Biotechnologies des plantes et Ethnobotanique, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, 06000 Bejaia, Algérie
3 Unité de Recherche Biologie des plantes et Innovation BIOPI EA3900-UPJV, PFA-UPJV, SFR Condorcet FR CNRS 3417, UFR des Sciences, Université de Picardie Jules Verne, 33 rue Saint Leu, 80039 Amiens cedex, France
*Corresponding Author: Corresponding author: Mostapha Bachir-bey, Email: , Email: mostapha.bachirbey@univ-bejaia.dz


Background: Fumaria officinalis is largely used in traditional medicine due to its efficiency in the treatment and prevention of numerous diseases and its large spectrum of therapeutic effects. Its multiple beneficial properties are due to its richness in bioactive substances, particularly isoquinoline alkaloids. However, few studies have addressed the toxicity of this plant.

Objectives: The present work aimed to study acute and subacute toxicity of alkaloids extracted from F. officinalis using Swiss albino mice as the in vivo model.

Methods: Alkaloids from the aerial parts of F. officinalis were extracted and administered to male and female Swiss albino mice. The acute and subacute toxicities were studied by monitoring the weight and histopathological study of animal bodies and organs (e.g., liver, heart, spleen, and kidneys).

Results: The results revealed that mice treated with increasing doses developed serious symptoms of toxicity (i.e., respiratory problems, tremors, coma, and paralysis leading the death) and lost weight. The LD50 was estimated at 1341.11 mg/kg permitting its classification as a low-toxic plant. The microscopic observations demonstrated disturbances in the kidney and liver, but not the heart and spleen.

Conclusion: The alkaloids of the aerial parts of F. officinalis expressed severe toxicity in mice, particularly at high doses. Nevertheless, the neutral fraction of alkaloids is more indicated.

Please cite this article as follows: Yahiaoui S, Khamtache-Abderrahim S, Otmani A, Bachir-bey M, Kati DE, Lequart-Pillon M, et al. Evaluation of acute and subacute toxicity of fumaria officinalis alkaloids in mice. Avicenna J Med Biochem. 2022; 10(2):128-134. doi:10.34172/ ajmb.2022.2383
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