The investigation of plasma MicroRNAs as a noninvasive biomarker for prediction of In-Stent Restenosis

Abstract

Background: In stent restenosis (ISR) is a detrimental complication which take places following coronary stenting. There is strong evidence that MicroRNAs(miRNAs) are involved in inflammation and neointimal formation. Ojectives: The current study was intended to explore the role of some circulating miRNAs in restenosis patients. Methods: A total 62 patients enrolled in this study. According to angiography, patients were grouped into restenosis group and non-restenosis. Plasma level of miR 21, miR126, miR143/145 and miR222 was analyzed with quantitative real-time PCR. Results: The plasma expression level of miR21(p=0.003) was higher significantly, vs control group. Also, plasma level of miR126(p=0.004), miR143(p=0.003) and miR145(p=0.008) were lower significantly in ISR group in compared with control group. In ISR group, plasma level of miR222 was increased, but not significant (p=0.08) Conclusion: The results revealed differential changes in plasma level of miRNAs. Some miRs may have critical function in restenosis pathogenesis and others may have protective effect. Totally, it is proposed predictive role for miRs following interventional therapy.

Keywords: Restenosis, inflammation, miR21, miR126, miR143, miR145