Submitted: 05 Feb 2015
Revised: 12 Feb 2015
Accepted: 22 Feb 2015
First published online: 25 Mar 2015
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Avicenna J Med Biochem. 2015;3(1): e27826.
doi: 10.17795/ajmb-27826
  Abstract View: 346
  PDF Download: 214
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Research Article

The Impact of G1575A Matrix Metalloprotease-2 Gene Polymorphism on Male Fertility

Aboozar Mohagheghi 1, Iraj Khodadadi 2, Manoochehr Karami 3, Iraj Amiri 4, Heidar Tavilani 5 *

1 Student Research Committee, Hamadan University of Medical Sciences, Hamadan, IR Iran
2 Department of Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran
3 Modeling of Non-Communicable Diseases Research Center, Department of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, IR Iran
4 Research Center for Endometr and Endometriosis, Hamadan University of Medical Sciences, Hamadan, IR Iran
5 Urology and Nephrology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran
*Corresponding author: Heidar Tavilani, Urology and Nephrology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran. Tel: +98-8138380462, Fax: +98-8138380208, Email: tavilani@umsha.ac.ir

Article

Background: Matrix metalloproteinases contain more than 20 enzymes that require zinc for their activities. Gelatinases are one of the subtypes of matrixmetalloproteinases, which degrade gelatin and collagen type 4, and are present in male reproductive tissues such as in prostate. G1575A Matrix Metalloproteinase-2 (MMP-2) gene polymorphism affects MMP-2 activity.

Objectives: The aim of this study was to investigate the prevalence of G1575A matrix metalloproteinase-2 gene polymorphism in fertile and infertile men.

Patients and Methods: In this study 200 fertile men as controls and 200 idiopathic infertile men as cases were investigated. For genotyping thefertile and infertile group the Polymerase Chain Reaction–Restriction Fragment Length Polymorphism (PCR-RFLP) method was used.

Results: Genotype frequencies of G/A in fertile and infertile men were significantly different (χ2 = 4.16, df = 1, p = 0.041). Genotype frequencies of G/G and A/Ain fertile and infertile men were not significantly different (χ2 = 3.32, df = 1, P = 0.068 and χ2 = 0.521, df = 1, P = 0.47, respectively). The risk of infertility was 1.43 folds higher in individuals with the A/A genotype compared to those with the G/G genotype. In men with the A/A genotype the risk of infertility was 2.14 folds higher than individuals with the G/A genotype.

Conclusions: These finding suggests that genetic variation of MMP can affect male infertility

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