Maryam Esfahani
1 
, Mohammad Taghi Goodarzi
2* 1 Ph.D. in Clinical Biochemistry, Nutrition Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2 Professor of Clinical Biochemistry, Department of Biochemistry, Shahrood Branch, Islamic Azad University, Shahrood, Iran
*Corresponding Author: *Corresponding author: Mohamad Taghi Goodarzi, Department of Biochemistry, Shahrood Branch, Islamic Azad University, Shahrood, Iran. Tel: +98 23 32390360 Fax: +98 23 32390077 , Email:
mtgoodarzi@yahoo. com
Abstract
ANGPTL8, a new hormone, is regarded as a novel target for type-2 diabetes and associated metabolic disorder. Nutritional state and hormonal factors are involved in the regulation of ANGPTL-8 expression. This protein is associated with some myokines or adipokines. Several studies confirmed the function of ANGPTL-8 in glucose metabolism and diabetes complications; however, there are opposite results. The accurate function of ANGPTL-8 in T2D remains unclear. Further strictly controlled studies including measuring methods, nutritional state, diagnostic criteria of overweight/obesity, age, and ethnicity may help to resolve discrepancies. In addition, more studies are demanded to clarify the potential role of ANGPTL-8 in humans, a cause or an effect of this protein in association with insulin resistance, the regulatory mechanism of ANGPTL-8 expression, and the association of ANGPTL8 with other adipokines or myokines. In this mini review, we described various roles of ANGPTL-8 in diabetes.